Let Aesthetic Bioregulating Therapy to restore what time had taken away...

Mesotherapy (Greek ‘mesos’ meaning ‘middle’) – subcutaneous and intradermal administration of highly diluted medicines using micro injection technique.

Homeopathic Mesotherapy boosts the health of the skin as well as the appearance. It can be used to treat every kind of skin conditions from acne to cellulite and can be administered as adjuvant therapy in skin cancer (at the distant site).

This type of skin therapy is a part of Aesthetic Integrated Medicine which combines therapeutic approach and principles of modern homeopathy and nutrition with elements and methods of conventional aesthetic medicine. It can work hand in hand with other therapies including acupuncture, Colour and Scenar Therapy, and many of the remedies used are similarly supported either by observation studies or clinical trials. 

“Beauty” has always been associated with good health and inner peace or inner beauty that includes psychological factors such as personality, intelligence, grace, charm and elegance. External beauty is reflected in having young, smooth and glowing skin and perfect body contour. Obviously, inner beauty develops when we are older; external or outer beauty is mostly associated with youth. Aesthetic homeopathic mesotherapy can help those who feel great inside to improve their outer beauty to create a perfect harmony.

Skin ageing is a complex and dynamic process which can be divided into two types: extrinsic ageing and intrinsic ageing. Intrinsic ageing (or chrono-ageing) is natural ageing resulting from hormonal changes, tissue loss, fat cells re-distribution and genetic polymorphism. Extrinsic ageing relates to external factors such as sun damage, smoking, poor lifestyle habits and free radical damage. It is external ageing that makes one look older than their age due mainly to sun damage and poor lifestyle.

Skin Structure.

We all understand that to slow down the skin ageing process the good practice would be to look after your skin in the same way as you would do to your baby: feed, clean and protect from extreme environmental factors.

Well, mesotherapy is all about feeding your skin with all the nutrients it needs to look healthy and vibrant. However, unless these nutrients can be delivered to its site of action, into the inner layers of the skin, the efficiency of the feeding process is compromised. In similar way your baby will stay hungry if the food you give him goes elsewhere, but not in his mouth.

The phenomenal advances in the fields of biotechnology and molecular biology led to the development of sophisticated skin care products containing not only beneficial to skin vitamins, minerals and aminoacids but also peptides, proteins and polysaccharides. Proteins and polysaccharides are the building blocks of our skin, and the skin starts ageing when the shortage of the building materials takes place at the building site.

Evolution has provided the mammalian organism with an external covering, the principal function of which is to act as a barrier, specifically to the loss of tissue water. Just think: the concentration of water inside the human body is in the order of 50M, while that in the atmosphere is clearly very much less. Thus, there is a strong driving force for water to be lost from the body, and to prevent desiccation, an efficient barrier at the interface is therefore required. The skin’s outermost layer, the stratum corneum, provides this shield. In doing so, the skin presents a formidable resistance to the absorption of molecules which contact the external surface.

As you may see from the picture of the Skin Structure above, the epidermis is stratified, keratinising epithelium. The keratinocytes comprise the major cellular component (>90%) and are responsible for the evolution of barrier function. The stratum corneum is usefully thought of as a ‘brick wall’ with the corneocytes comprising the ‘bricks’, embedded in the ‘mortar’ created by intercellular lipids.

Thus, due to very tight ‘mortar’ junctions, the absorption of molecules from topically applied cosmetic creams, serums and lotions will be limited to very small size molecules such as vitamins, minerals, aminoacids and at most small peptides. Large molecules such as proteins (e.g. collagen) and polysaccharides (e.g. hyaluronic acid) are not able to penetrate through stratum corneum barrier. The only possible way of absorption for these molecules by passive diffusion into the skin is via hair follicles and sweat ducts that in total constitute only half percent of the skin surface area. This can not be considered efficient in terms of therapeutic macromolecules bioavailability. Therefore assisted penetration using subcutaneous and intradermal injections of therapeutic peptides, proteins and polysaccharides or transdermal mesotherapy method are the most effective ways of delivering crucial to ageing skin ‘building materials’ to the site of action.

In general, absorption rates of active ingredients into the skin are as follows:

10% from topically applied skincare products

40% with the use of Needle-Free Transdermal Mesotherapy devices (electroporation method)

60% with the use of Mesorolling (also known as dermarolling) technique

100% with the use of intradermal/subcutaneous injections (mesotherapy)

Results of the observation studies into the efficacy of homeopathic remedies in minimising appearance of wrinkles and facial skin slackening, are as follows:  

  1. Skin nourishment with enhanced bioavailability of nutrients due to intradermal delivery using mesotherapy injection technique
  2. Skin texture and colour improvement
  3. Skin hydration and firmness improvement due to stimulation of skin hyaluronan and collagen synthesis
  4. Stimulation of skin microcirculation
  5. Skin detoxification and restoration of metabolic rate
  6. Skin revitalisation and tonification

Results of treatment for facial revitalisation with mesotherapy OTI method (before and after).

Superficial skin volume (thanks to mesotherapy effects) makes our face look healthier. However, mid-face cheeks volume makes our face younger, even if skin texture is not perfect, as per example pictures below:

Belotero® is a Hyaluronic Acid based dermal filler that is suitable for smoothing the wrinkles and volumising the lips, as per example pictures below:

Results of melasma (skin hyperpigmentation) treatment with OTI method (after and before).

Results of 'crow's feet' treatment with BNT (before and after).

Old and new skin scars: advice and treatment available. Old scars (over 4 years) require clinical-based treatment plus continuous home treatment. Prices differ depending on the size - please contact for quotations.

Results of non-invasive scar treatment (before and after).

LED Light Phototherapy

'The non-invasive LED Light Phototherapy was shown to be effective in treatment of several aspects of skin ageing from fine lines and face lift to acne and hyperpigmentation. This treatment is most effective if combined with application of good quality skincare product and preliminary session of microdermabrasion. In particular, the Blue LED Light Phototherapy with application of thick layer of DMAE Face Lift cream aka mask for 20 minutes produces immediate visible face lift (see the above picture).

The Red LED Light Phototherapy can be used for skin rejuvenation or acne treatment in combination with specific skincare products containing vitamin C or Wild Yam and Manuka MGO.

The price for one LED Light Phototherapy session: £65.00.

One session of LED Light Phototherapy combined with Microdermabrasion: £99.00 (contraindicated in case of inflamed acne). Recommended course of treatment: six weekly sessions.

Mesotherapy Products

Sterile preparations for mesotherapy are mainly complex cocktails of herbal or homeopathic and natural to the body components such as vitamins, aminoacids, Krebs cycle catalysts, coenzymes, proteins such as collagen and elastin and glucosaminoglycans such as hyaluronic acid – some prepared homeopathically in the lowest homeopathic dilutions or being diluted using sterile saline solution to almost homeopathic concentration prior to injections. When administered over a full course of in average eight treatments, they provide visible and long lasting results.

Homeopathic medicines containing highly diluted active ingredients have no side effects or contraindications and can be used even during pregnancy. No patch tests are therefore required.

The remedies such as Bioteg, OTIcatal, hyaluronic acid, DMAE (OTI Srl.); MADE® (Guna Srl.); collagen (OTI Srl., Heel GmbH, Guna Srl.) can be used both as a treatment for reducing the signs of aging and as preventive treatment for maintaining youthful face. Lecitin, Dehydrocholic acid, Cellitin, Fucus and many others are used for the treatment of cellulite and for body contouring. The remedies manufactured by OTI Srl. are suitable for transdermal mesotherapy.

Beauty products from OTI Officine Terapie Innovative Srl., the manufacturing company established since 1978 situated in one of the most beautiful rural mountainous areas of Italy called Abruzzo (50 miles to the East from Rome).

Injectable remedies for facial mesotherapy not only add volume and smooth out imperfections (this is a shorter term effect compared to the fillers and botox), but mainly produce accumulative and longer lasting regenerating effect on the dermis.


The course of treatment usually consists of six to ten sessions on a weekly basis: two sessions in the first week, then one session per week for the consecutive weeks. Maintenance treatments are recommended on monthly basis for three months after completion of the course. Achievement of stable skin rejuvenation results usually requires four treatment courses over two consecutive years.

Prices for areas:

whole face: £69.00

face and neck: £79.00

face, neck, hands or decollete: £89.00

Prices for cellulite symmetrical areas (e.g. hips, buttocks):

One area: £75.00

Two areas: £85.00

Three areas: £95.00


The aesthetic treatment approach is not the same for everyone and the treatment course will be carefully tailored to you. It is advisable to start with mesotherapy slimming/body contouring programme (if required) before facial revitalisation course. However, the facial revitalisation programme also should start with facial contour correction (e.g. double chin reduction) followed by the course of mesotherapy to improve skin condition, and finished with facial wrinkle relaxation and volume augmentation treatments using Botulinum toxin and dermal filler injections.

Before you are treated, you skin must be clean, so any makeup or cosmetics must be removed using preferably astringent or facial cleansing product. Use cold water to ensure that your pores are not dilated. It is strongly recommended that no blood thinning/circulation increasing products such as Aspirin, Niacin, Omega-3 fish oil or alcohol are taken at least 3 to 4 days prior to your treatment as they may increase bruising and swelling at the injection site. The effects of homeopathic injectable medicines may include temporary mild inflammatory reaction such as redness in the injected area and temporary swelling and/or nodules or mild bruising at the injection site. You will be asked to complete Medical History and Patient Consent forms before the first treatment and also will be given a Book of Patient Treatment Records. Your practitioner will insert a fine short needle in the desired location. Swelling and redness will usually subside within hours and you can get back to your daily routine with little down time. Topical anaesthetic cream can be used to minimise discomfort of the procedure.

Injection sites on the face.

After the treatment try to keep your face relaxed and refrain from exposure to extreme heat (sauna, bath, sunbathing) for one week after the treatment. The same applies to any facial procedures involving massage as this can cause the components of injectable medicines to break down more rapidly. It is not recommended to touch or massage the injected area unless advised otherwise. You can begin to re-apply your makeup and daily skincare products the day after your treatment.


Injection sites for cellulite treatment and body contouring.


Areas of inflammatory or infectious skin problems

Patients under the age of 18

Bleeding disorders or patients taking anti-coagulants (risk of bruising)
Fear of needles
Skin cancer or active keloid scars
Diabetes (insulin dependent)
Patients on long-term steroid therapy
Heart conditions
Allodynia or hyperalgesia (low pain threshold)

The injectable medicines used for mesotherapy treatments are only available through medical professionals or qualified in mesotherapy registered practitioners. The ideal candidates for Aesthetic Bioregulating Mesotherapy are men and women looking to improve or restore their skin texture and firmness, maintain youthful look, smooth out shallow wrinkles and imperfections on their face and improve their cellulite and body contour.

Best facial skin rejuvenation results achieved with combination treatments that include skin peeling using mandelic, salicylic, glycolic acid peels, skin microneedling (also known as mesorolling or dermarolling) using either 0.3, 0.5, 1.0 or 1.5 mm needle size mesorollers and mesotherapy (ask your practitioner for additional information).

While mesotherapy and mesopeel works very well for slimming, cellulite and stretch-marks reduction, body contour and improvement of skin qualities such as texture, firmness and colour, it is not immediately effective against loss of facial volume associated with ageing. It is well known fact that our faces loose volume and contour with age. Youthful facial appearance means optimal volume distribution, taut skin, clear contours, 'V' shape of face. A sign of ageing comes with increased loss of facial volume, slackened conours, wide chin line, inverted 'V' shape of face. When those signs start appearing - it is time for Dermal Fillers such as Radiesse®, Belotero® or Ellansé. Radiesse® is a dermal filler with high viscosity (calcium hydroxyapatite) therefore is very effective for volumising facial features such as cheeks, chin, deep (fibrotic) nasolabial folds giving the extra benefits of collagen induction in the skin. Ellansé is a PCL (polycaprolactone, material used in surgical sutures) based biostimulatory dermal filler with built-in sustained performance system. PCL microspheres stimulate neo-collagenesis to replace the volume of the resorbed carrier providing restoration of youthful look of face and hands. Belotero® is a Hyaluronic Acid based dermal filler that is suitable for smoothing the wrinkles and volumising the lips. The same contraindications apply to the use of Dermal Fillers as to Mesotherapy (see above). Prices for treatment with dermal filler range from £250 for upper lip augmentation (using one syringe of Hyaluronic dermal filler including dental block) to £580 for cheeks augmentation using two syringes of Radiesse or Ellansé. Other areas of treatment include nasolabial folds, marionette lines, prejowl sulcus and mental crease. Treatment price varies depending on individual needs, product brand and amount used. Price for dermal filler treatment includes follow-up correction for volume diminishing treatment using enzyme injection if required. Top-up correction is available at additional price at the cost of material used. For those having profound 'frown lines' between the eyebrows (also called 'glabellar lines') the Bocouture® (purified Botulinum neurotoxin of MW 150 kDa) injections is a recommended standard treatment as it weakenes the underlying muscles who's repetitive contraction causes formation of the lines and wrinkles. Each client is required to be assessed by a doctor prior to treatment with Botulinum neurotoxin (BNT).*


Conditions with pathological neuromuscular transmission e.g. myasthenia gravis, MS

Those on aminoglycosides, cyclosporine, quinidine, aminoquinolones, magnesium sulfate therapy

History of anaphylactic shock


Age of under 18 and above 65

Those who are allergic or developed resistance (IgG antibodies) to Botulinum neurotoxin type A

Those who are due to have surgery

Price £20 per each point of injection in the following areas: frown (glabellar) lines, crow's feet, forehead lines and cobbled chin.

Minimal charge of £168 applies for a treatment of one area only. Usual treatment of three areas such as glabellar lines, crow's feet and forehead lines involves injections in 15-16 points, however the treatment will be individually tailored to address each client's aesthetic needs. Top-up treatments with BNT are not available or/and advisable.

*Treatments involving BNT administration usually take place at Vitality dental clinic on St. James St. in Derby.The initial consultation is required for each new client (the price of £15 refundable at the time of payment for the first treatment).

For more detailed information please visit www.merzaesthetics.eu/en and/or www.ellanse.com or contact Alla Cranham.


OmeoNet Journal, pilot issue 2008

Martines Image course lectures, 2009

Biological Mesotherapy in Aesthetic Medicine by Dr. E. Sazhina. Holistic Cure, 2008

Stedman’s Medical Dictionary, 5th edition. Lippincott Williams & Wilkins, 2005

Clinical Medicine, by Kumar & Clark, 6th edition. Elsevier Saunders, 2005

Drug Delivery and Targeting for Pharmacists and Pharmaceutical Scientists. Taylor & Francis, 2001

Advanced Professional Skin Care, medical edition by P.T. Pugliese, MD. The Topical Agent, LLC, 2005

Merz Aesthetics, Ellanse specialist literature

Botulinum Toxin in Aesthetic Medicine, by Mauricio de Maio & Bertold Rzany. Springer, 2007

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