Homotoxicology evolved from a need to provide a bridge between classic homeopathy and conventional medicine to form an Integrated Medicine. 

Based on practical experience, German doctor Hans-Heinrich Reckeweg (1905-1985) developed an integral theory of illness and healing which he called Homotoxicology. He stated that all body actions and reactions such as moving muscles, metabolism, brain activity etc. manifest themselves only via chemical reactions of body compounds.

Toxic substances are called by Dr. Reckeweg homotoxins and diseases caused by them homotoxicoses.
He realised that homeopathic remedies produce antihomotoxic effects and must be active in individual symptoms. Unlike in homeopathy, antihomotoxic remedy is not directed against symptoms, but against homotoxins that induce these symptoms. This is the scientific basis of homotoxicology which bridges homeopathy with mainstream medicine.


Homotoxicology differs from Classic Homeopathy:

·     While homeopathy uses single remedy, antihomotoxic medications represent synergistic combination of herbal, mineral, biological, pharmaceutical and/or biopharmaceutical ingredients prepared homeopathically since several tissue-incompatible substances are usually involved during the disease development.

·     While with homeopathic remedies stronger therapeutic effect is produced with the highest dilutions, antihomotoxic medicines are always prepared in low and medium homeopathic dilutions with D12 dilution being the accepted borderline.

·    While homeopathic therapy is based on symptoms, antihomotoxic medicine usually follows an indication-oriented approach.

Homotoxicology, as integrated holistic bio-regulatory system of medicine, also differs from conventional medicine by making the PATIENT, rather that the signs and symptoms of the condition, the main focus of interest.

Homotoxicology sees any illness occurrence due to the accumulation of homotoxins in the body, whether of external or internal origin.

·       external (exogenous) homotoxins are introduced from external sources due to environmental pollution or poor life style habits. We live in a world surrounded by toxins. Every year, about 1000 new chemicals are released on the market, many not fully tested for their effects on the human body. Some are so called PBTs or Persistant Bioaccumulative Toxins, meaning that they are present in the environment and in our food chain for a long time. These are substances such as pesticide residues (e.g. DDT), polychlorinated biphenyls (PCBs), dioxins and plasticizers. Other more common exogenous toxins include food additives, chemical ingredients used in body care products, cigarette smoke, etc.

·        internal (endogenous) homotoxins originate in the body itself as end products of our metabolism, such as histamine, adrenalin etc.; or as result of mutated genes malfunction; or genetic polymorphism in combination with unsuitable life style (e.g. Coeliac disease has genetic predisposition factor but will only develop if the person subjects themselves to the consumption of gluten containing foods, hence ‘you are what you eat’). 

accumulated in the body, the effects of homotoxins range from immunotoxicity to endocrine disruption and may also affect the nervous system, vital organs, cellular respiration, antioxidant reactions as well as mucosal surfaces. Some may even be carcinogenic.

The anti-homotoxic therapy focuses on ground system (extracellular matrix which plus cellular, humoral and nervous components), the first site for homotoxins deposition which also serves as a site for intercellular communications and immunological reactions (see picture below ).

Ground System.


The extracellular matrix (ECM, which forms a part of connective tissue) represents a combination of collagens, non-collagenous glycoproteins, and proteoglycans (ground substance) surrounding cells of the connective tissue. Epithelial and non-epithelial cells have receptors (transmembrane family of integrin proteins) with binding affinity to ECM constituents such as cell-adhesion molecules fibronectins and laminins.

Fibroblast is the metabolically active regulation centre corresponding to a glial cell of CNS (Central Nervous System). Fibroblast reacts immediately to all incoming information such as hormones, neurotransmitters, catabolites, metabolites, pH changes etc. an synthesises the matrix substances to suit the current situation within the ECM. Fibroblasts can not differ between bad or good information

Proteoglycans (PGs) are major components of the ECM and consist of a core protein, covalently linked to glycosaminoglycans (GAGs, or formerly mucopolysaccharides). Hyaluronic acid backbone is non-covalently linked to core proteins via linker proteins thus forming Proteoglycan aggregates involved in cross-linking the collagen fibrils of cartilage matrix (the whole structure is sensitive to pH change that makes it prone to instability):

Proteoglycan Aggregate.

PGs and GAGs are negatively-charged and therefore are able to bind water via hydrogen bonds formation and exchange ions as well. Therefore they are guarantors for isoionic (removal of any other ions except for those arising from dissociation of solvent and solute), isoosmic (osmotic pressure balancing) and isotonic processes in matrix (tension regulating) processes.

There is reciprocal relationship between capillary system, ground substance, terminal autonomic axons, connective tissue cells (mast cells, fibroblasts etc.) and  parenchymal cells (tissue constituting the essential or specialised cells of the organ, e.g. parenchymal cells of liver - hepatocytes). Epitelial and endothelial cell groups rest on the basal membrane which mediates it to the ground substance. Every cell has glycoprotein surface receptors including MHC (major histocompatibility complex) with connections to the ground substance. The ground substance is connected with endocrine system via capillary system, and  with central nervous system via axons. And both the CNS and ES are connected to each other via brainstem and overlaid brain centres.

Due to the sieving well as connective properties of the ground substance (PG/PGA), the matrix can become sluggish through development of latent tissue acidity, free radicals increase and trigger of proteolytic degradation processes leading to pro-inflammatory situation. Eventually, damage to all humoral and cellular components may be a result of progression from the feelings ill health to chronic diseases and malignant processes.

The Ground Regulation  is regulation of the ground system along with superimposed nervous, hormonal and humoral (related to the blood or body fluids) regulation systems. The system of Ground Regulation constitutes the scientific basis of bio-regulatory medicine.

All reactions in the living organism occur at relatively low temperatures in the aqueous media, therefore they must be accelerated, i.e. catalyzed. The prerequisite for an effective catalysis is availability of suitable substrates within the cells and within intracellular space. As the cells are in direct contact with extracellular space, they can only react to the signals coming via the extracellular space. Therefore the dynamic structure of extracellular space and its regulation (‘GROUND REGULATION’) have a decisive impact on the effectiveness of extracellular and intracellular catalysts. This depends on the structure of the ECM. ECM forms a molecular sieve of matrix components in all cell groups.

Both Reckeweg’s homotoxin theory and antihomotoxic therapy with homeopathic single and combination remedies are based on humoral pathology, that is, Reckeweg saw the organism as a fluid system in the humoropathological sense. Tolerated substances produce no disturbances in the body’s steady state, while toxic substances trigger defesive measures that are perceived as illness.

One of the fundamental concepts of homotoxin theory is that all manifestations of life, whether physiological or pathological, are subject to the laws of chemistry.

Metabolic reactions need to occur in a proper environment, free of waste materials and within an ideal pH range. When there is a build-up of toxins in certain areas of the body, the natural chemical reactions become slower and of poorer quality, which in turn, can affect all of the body’s functions. As the quantity of toxins increases, the reactivity potential (natural defence mechanisms) of the individual decreases and the body’s capacity to detoxify itself is lessened or even hindered. Thus, this may translate into an evolution of pathologies towards irreversible stages where they become chronic, degenerative or out of control (neoplasm). Many diseases that may then appear are directly related to the body's incapacity to rid itself of its toxins.

Dr. Reckeweg’s Six Phase Table of disease evolution illustrates the chronological courses of various symptoms of disease within the structure of the ground regulation. The table is subdivided into three sections: (humoral phases, matrix phases, cellular phases), each of which is subdivided into 2 phases. Each two phases are allocated to the excretion principle (phase 1+2); the deposition principle (phase 3+4); and the degeneration principle (phases 5+6).

Thus 3 main phases of disease evolution depend on the location of homotoxins which can be located:

1.    Within body fluids (the associated phase of disease is called HUMORAL, e.g. heart burn, gastritis) – these are the easiest to eliminate, sometimes event detox dieting may help. Inflammation (which is a cyclical process) is referred to a Humoral phase and could serve as a trigger point for further disease development within the Matrix phase if not dealt with properly and/or in time.

2.      Within connective tissue (the associated phase of disease is called MATRIX phase, e.g. IBS, gastric ulcers) – these are more difficult to eliminate and specific remedies are required.

3.      Within the cells of tissue (the associated phase of diseases is called CELLULAR phase, e.g. Crohn’s disease, gastric cancer) – these are the most difficult to eliminate, requiring application of specific protocols that include enhancement of the cellular metabolic pathway and cellular respiration (Krebs cycle).


When there is a build-up of homotoxins in certain areas of the body, the natural chemical reactions become slower and of poorer quality, which in turn, can affect all of the body’s functions. As the quantity of toxins increases, the reactivity potential (natural defence mechanisms) of the individual decreases and the body’s capacity to detoxify itself is lessened or even hindered. Thus, this may translate into an evolution of pathologies towards irreversible stages where they become chronic, degenerative or out of control (neoplasm). Many diseases that may then appear are directly related to the body's incapacity to rid itself of its toxins.

Regulation/Compensation division (formerly Biological division) – imaginary boundary between the deposition and impregnation phases (or between the states of health and disease). It separates the pure deposition in the matrix from integration of toxins into its structural components.  Whereas excretion of toxins is possible in deposition phase, the structural and functional changes are found in impregnation phase. Thus spontaneous endogenous excretion of homotoxins is suppressed.

Vicariation – transition of the indicating signs of illness within one phase to another organ system (comorbid conditions appearance), or the transition of fundamental symptoms and signs into another phase within the same organ system.

Progressive vicariation – aggravation of total symptoms and signs of illness (disease progression).

Regressive vicariation – improvement of the total symptoms and signs of illness (recovery).

Please click here for the Six-Phase Table file

The Greater Defence System

In the human or animal body there is a sophisticated system of interconnected defensive mechanisms that eliminates toxins and repair damage. With the help of these mechanisms homotoxins are either eliminated or combined with other substances to form harmless compounds called homotoxons. This entire system of detoxification mechanisms in Homotoxicology is called The Greater Defence System. It consists of five subsystems:

 1.      Reticuloendothelial system (humoral defences): 

·          storage of poisons

·          antibody formation

 2.      Adenohypophyseal-suprarenal-cortex defensive subsystem (humoral defences):

·          regulation of suprarenal gland cortex 

·          connective tissue stimulation

·          inflammation arrest

 3.      Neural reflexes (neural defences)

·          excitation or irritation syndrome

·          neural therapy

·          acupuncture

 4.   Detoxification in the liver (humoral defences)

·          acid linkage

·          toxin storage

·          neutralising to homotoxons

·          properdin system

 5.  Connective tissue detoxification function (humoral and cellular defences)

·          storage of toxins

·          antibody to antigen binding

·          inflammation

·          leucocytes formation

·          lymphocyte and macrophage mediated defences


Therapeutic approach in Homotoxicology is to treat illnesses by detoxifying the affected organs and systems using specific complex medicines combining homeopathic and pharmaceutical ingredients in very low concentrations (i.e. in nanograms rather than milligrams as in pharmacology) prepared homeopathically. For example, homeopathic pulsatilla and sulphur are combined together with homeopathically diluted cortisone in one formulation which allows for correction of certain type of regulation rigidity in a cyclic process of inflammation. These medicines are available in the U.K. in the form of tablets, drops, creams, gels and ampoules only on prescription from a registered homotoxicologist or a medical professional.

The therapeutic approach in Homotoxicology is based on THREE PILLARS:

  1. DETOXIFICATION AND DRAINAGE (binding of free radicals, trace elements and mineral balance) 
  1. IMMUNOMODULATION (Immunological Bystander reaction or Type IV hypersensitivity reaction) 
  1. CELLULAR ACTIVATION AND ORGAN REGENERATION (cellular respiration, Krebs cycle support and organ support with porcine or recombinant proteins)

The Deposition phase and more frequently Impregnation phase is characterised with immunological processes such as chronic inflammation and auto-aggression.

A D1-D14 dilutions of antihomotoxic remedies contain sufficient amount of substance to induce stimulation of macrophages to produce antigen motif (chain of 9-15 amino acids) after phagocytosis of the whole antigen molecule. This is the prerequisite for production of regulatory lymphocyte Th3 (T-helper cell). The Th3 cells find Th, Th1 and Th2 lymphocytes with similar antigenic motives and suppress them by releasing the anti-inflammatory cytokines TGF-β (transforming growth factor β) and some of the IL-4 and IL-10 (interleukins). TGF-β is the most potent anti-inflammatory cytokine in the body. At the same time the B-lymphocytes are stimulated to elaborate antibodies.

Immunological Bystander Reaction diagram.

It is important here to note that production of Th3 cells can take place only in the low-dose antigen range (i.e. from D1 to D14). Greater antigenic protein concentrations inhibit formation of Th3 cells, and high dilutions do not allow for the production of motifs.

Antihomotoxic remedies are particularly suitable for this purpose because due to its animal or other heterologous protein content in dilution between D1 and D14, they can produce a Bystander Reaction.
The other potentised substances in antihomotoxic remedies are useful for maintaining basic regulation.

The field of medicine these days experiences a shift from devastating infectious diseases to chronic and degenerative disorders. In 1990 the proportion of chronic to acute disease was 1:1 – today it is 9:1.

While acute illnesses are successfully treated with pharmaceutical drugs, the best therapeutic approach for chronic illnesses lies within holistic biological medicine. Biological therapy does not strive for a collision with the proven conventional therapy forms. It is performed additionally and complementarily.

Therapeutic approach in Homotoxicology had been successfully used in:

·            Chronic and degenerative conditions such as acne, arthritis, asthma, cataract, eczema, IBS etc

·            Unstrained weight loss programme

·            Preconception detox programme

·            Rejuvenation for him and her

·            Diabetes and cancer prevention

·            Post-chemotherapy recovery programme

Our self-preservation instinct tells us to take care of ourselves. With today’s modern technology our longevity is in our hands, and express evaluation of health on the Health Detector scan combined with therapeutic methods of Homotoxicology will help you to exert control over this.



·          Homotoxicology and Ground Regulation System (GRS), by Hartmut Heine. Aurelia-Verlag, 2003

·          The Fundamentals of Homotoxicology. Diagnosis and Therapy of homotoxicoses, by Gabriele Herzberger.    Aurelia-Verlag, 2003

·          Kuby Immunology, W.H.Freeman, 2001

·          Color Atlas of Genetics by Georg Thieme et al.  University of Essen, 1995

·          Biotherapeutic Index, by Biologische Heilmittel Heel, 2000.

·          Histology and Cell Biology, by Abraham L. Kierszenbaum. Mosby, 2002

·          Oxford Dictionary of Biochemistry and Molecular Biology. Oxford University Press, 2001

·          Stedman’ Medical Dictionary, 5th edition. Lippincott Williams & Wilkins, 2005


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